Table 2 Gene set enrichment analysis Gene set enrichment analysis of genes in size class 1 showing evidence of intron content conservation in mammals. Top twenty most significantly enriched terms are shown.

UP_SEQ_FEATURE

DNA-binding region:Homeobox

20

2 × 10^–10

8 x 10^–8

INTERPRO

Homeobox, conserved site

20

9 × 10^–10

2 x 10^–7

SP_PIR_KEYWORDS

Homeobox

20

2 × 10^–9

4 x 10^–7

INTERPRO

Homeobox

19

5 x 10^–9

6 x 10^–7

GOTERM_BP_FAT

Regulation of transcription, DNA-dependent

41

7 x 10^–9

1 x 10^–5

INTERPRO

Homeodomain-related

19

1 x 10^–8

8 x 10^–7

GOTERM_BP_FAT

Regulation of RNA metabolic process

41

1 x 10^–8

8 x 10^–6

GOTERM_BP_FAT

Positive regulation of transcription from RNA polymerase II promoter

19

1 x 10^–8

6 x 10^–6

GOTERM_BP_FAT

Positive regulation of biosynthetic process

27

3 x 10^–8

1 x 10^–5

GOTERM_BP_FAT

Positive regulation of cellular biosynthetic process

27

3 x 10^–8

1 x 10^–5

GOTERM_MF_FAT

Transcription regulator activity

38

7 x 10^–8

2 x 10^–5

GOTERM_BP_FAT

Positive regulation of gene expression

24

8 x 10^–8

2 x 10^–5

GOTERM_BP_FAT

Positive regulation of transcription, DNA-dependent

21

8 x 10^–8

2 x 10^–5

GOTERM_BP_FAT

Positive regulation of RNA metabolic process

21

8 x 10^–8

2 x 10^–5

GOTERM_BP_FAT

Positive regulation of macromolecule biosynthetic process

25

9 x 10^–8

2 x 10^–5

GOTERM_BP_FAT

Positive regulation of macromolecule metabolic process

27

1 x 10^–7

2 x 10^–5

GOTERM_BP_FAT

Positive regulation of nitrogen compound metabolic process

25

1 x 10^–7

2 x 10^–5

GOTERM_MF_FAT

Sequence-specific DNA binding

25

1 x 10^–7

2 x 10^–5

SMART

HOX

19

2 x 10^–7

8 x 10^–6

GOTERM_BP_FAT

Positive regulation of transcription

23

2 x 10^–7

3 x 10^–5