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Table 1 Comparison of time complexity of OrthoMCL, GCFinder and SYNS All experiments have been run on the dual-core Intel Xeon 2.33 GHz server. Results are also available for MultiParanoid (approx. 2 hours run time) and CoCo-CL (approx 3 hours run time) for which no time complexity is found in literature.

From: Identification of conserved gene clusters in multiple genomes based on synteny and homology

Method

Time complexity

Execution time

Notations Used

OrthoMCL

O(Nk2)

76min (excluding Blast)

N = #genes, k = pruning constant

GCFinder

Ordered

Unordered

O(nd(k + d))

O(k2nD(tD + 1)k- 1)

1546min

interrupted after 3 days

n = #families

k = #genes, d = window size

D = max #genes in a window

t = max # paralogous copies of a gene in a chr.

SYNS

O(n((δ + 1) × c × t)4)

15min

n = #families, c = #chr., δ = window size, t = max # of paralogous copies of a gene in a chr.