Q ″-type functions, depending on ARI (a) Squam HPV dataset. (b) Adeno HPV dataset. Variation of the function Q"4, depicted by a dashed line, Q"5, depicted by a continuous line, and Q"6, depicted by a dotted line, obtained with the non-overlapping sliding window of width 20 nucleotides during the scan of the gene E6. The abscissa axis represents the window position along the nucleotide MSA. The PDZ-domain is highlighted in gray. Annotations for the N and C-terminal arms, E6N and E6C domains are represented for HPV16 coordinates, from (Nominé et al., 2006) . Zn2+-ligating Cys residues annotations reproduced from Lipari et al., 2001 .