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Table 2 Growth Inhibition verification of 2B/10A Compounds

From: Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs

Chemical

CMap (μM)

GI50 (μM)

Subcomponent

Cell line

berberine

10

25.1

2B

MCF7

irinotecan

100

6.3

2B, 10A

MCF7

mitoxantrone

7.9

0.004

2B

MCF7

amiodarone

6.3

4.0*

2B

PC3

8-azaguanine

25.1

0.32

10A

HL60

apigenin

15.9

25.1

10A

HL60

azacitidine

15.9

0.79

10A

PC3

camptothecin

12.6

<0.01**

10A

MCF7

chrysin

15.9

15.8***

10A

MCF7

methotrexate

7.9

0.03

10A

MCF7

thioguanosine

12.6

0.32

10A

MCF7

esculetin

25.1

>100**

10A

HL60

fulvestrant

1.0

>100**

10A

PC3

  1. GI50 values (drug concentration causing a 50% growth inhibition) from NCI/DTP are shown along with the corresponding concentrations used in the Connectivity Map (CMap) data. By comparing the GI50 and CMap values we can get an idea of expected cell killing effect of the drug in the CMap data. Drugs that are expected to eventually kill the cells are shown in bold. GI50 and CMap concentration values are in μM scales.
  2. * GI50 value at the end of the tested range.
  3. ** Mean of GI50 values from HL60 and MCF7 cell lines.
  4. *** Value from HL60 cell line.