Table 1 Selected examples of published associations with hypothesis-free testing of metabolite ratios
Metabolite ratio | Association | Interpretation | Reference |
|---|---|---|---|
SM(OH)C28:0/SM(OH)C26:0 | Diabetic (db/db) versus wild type mice | Increased beta-oxidation in diabetic mice | Altmaier et al., Endocrinology, 2008 |
PC aa C36:3/PC aa C36:4 | FADS1 genotype | Genetic variance in delta-5 fatty acid desaturation | Gieger et al., PLoS Genetics, 2008 |
PC aa Cx:y/PC ae Cx:y | Smoking | Reduced or lack of activity of the enzyme alkyl-DHAP in smokers | Wang-Sattler et al., PLoS One, 2008 |
PC aa C40:3/PC aa C42:5 | ELOVL2 genotype | Genetic variance in elongation of fatty acids | Illig et al., Nature Genetics, 2010 |
Medium chain fatty acids / long chain fatty acids | Diabetes state | Perturbed lipid metabolism associated with diabetes | Suhre et al., PLoS One, 2010 |
PC aa C40:5/PC aa C40:6 | Self-reported nutritional intake of polyunsaturated fatty acids | Confirmation of questionnaire based life-style parameters | Altmaier et al., Eur. J. Endocrinology, 2011 |
Ratios between phospholipids with lipid side chains from the C16:0, C16:1, C18:0, C18:1 pool and C20:3, C20:4, C22:4 PUFAs | Plasma, tissue (mouse) and cell lines (human) treated with FABP4 inhibitor | Molecular inhibition of FABP4 activity | Suhre et al., J Biomol Screen, 2011 |
Formate/ acetate in human urine | NAT2 genotype | Genetic variance in N-acetylase activity | Suhre et al., Nature Genetics, 2011 |
Ratio between phosphorylated and unphosphorylated fibrinogen peptides | ABO, ALPL, and FUT2 genotypes | Genetic variance in fibrinogen phosphorylation | Suhre et al., Nature, 2011 |