Table 1 Simulation parameter settings for the single-locus simulations

1

MOI

Dominant, Recessive, Multiplicative

2

ϕ

0.05, 0.15

3

R ₂

1.0 (Null), 2.25

4

π ₁

0.25, 0.50, 0.75, 1.0

5

p

0.10, 0.25, 0.50, 0.75, 0.90

6

Number of trios

1000

7

Number of permutations per statistic

500

8

Number of starting points

200

9

Number of EM steps per starting point

100

10

ε

10^-6

11

Penalty C in EM algorithm (Equation (1))

0.001

12

Number of replicates per vector (Items 1-3)

250