TDT-HET: A new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data

Table 2 Simulation parameter settings for the multi-locus simulations

Item	Parameter	Setting
1	Number of loci	4
2a	Locus transmission probability: MOI	Multiplicative
2b	Locus transmission probability: p	0.10, 0.50, 0.9
3	R ₂	1.0 (Null), 2.25,9.0
4	π ₁	0.25, 0.75
5	ρ	0.8

MOI = Mode of inheritance
p = Disease allele frequency
R₂= Genotype relative risk for disease allele homozygote
π₁= Proportion of linked trios
ρ = correlation coefficient. ρ = 1 (perfect correlation), ρ = 0 (no correlation)

ISSN: 1471-2105