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Table 2 Simulation parameter settings for the multi-locus simulations

From: TDT-HET: A new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data

Item Parameter Setting
1 Number of loci 4
2a Locus transmission probability: MOI Multiplicative
2b Locus transmission probability: p 0.10, 0.50, 0.9
3 R 2 1.0 (Null), 2.25,9.0
4 π 1 0.25, 0.75
5 ρ 0.8
  1. MOI = Mode of inheritance
  2. p = Disease allele frequency
  3. R 2 = Genotype relative risk for disease allele homozygote
  4. π 1 = Proportion of linked trios
  5. ρ = correlation coefficient. ρ = 1 (perfect correlation), ρ = 0 (no correlation)