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Table 2 Predefined gene-environment interaction models in GENS2

From: Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2

Interaction model Description
Genetic Model(GEN) Disease risk depends only on the genetics of an individual
Environmental Model (ENV) Disease risk depends only on environmental exposure of an individual
Gene Environment interaction Model (GEM) The genetics modifies the effect of the environment in modulating the disease risk
Additive Model(ADD) The effects of environment and genetics are independent and sums in modulating the disease risk