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Table 9 Modification of staple strands for DNA origami

From: EGNAS: an exhaustive DNA sequence design algorithm

 

Triangular DNA origami

 

Not yet modified

Modified staple strands

 

staple strands

Ding et al.

EGNAS

Average ΔG

-1.5 ± 1.4

-3.2 ± 1.7

-2.2 ± 1.3

Minimum ΔG

-5.2

-6.8

-5.2

 

Six-helix bundle nanotubes

 

Not yet modified

Modified staple strands

 

staple strands

Stearns et al.

EGNAS

Average ΔG

-1.36 ± 1.1

-5.9 ± 1.3

-1.8 ± 1.4

Minimum ΔG

-3.0

-8.0

-4.2

  1. Comparison of sequences that were generated by using EGNAS, and those used by Ding et al.[40] or Stearns et al.[41] to modify staple strands of triangular DNA origami or six-helix bundle nanotubes, respectively. Molar free enthalpies (ΔG, kcal/mol) of the most stable hairpins. Averages ± standard deviations.
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BMC Bioinformatics

ISSN: 1471-2105

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