Performance comparison. The comparison was made using the tools' default parameters on 16 proteins that have a total of 17 actual caspase-3 cleavage sites. The dashed line shows the actual number of caspase-3 cleavage sites. The black bars show the number of true positives predicted by each tool, while the gray bars (minus scale) show the number of false positives predicted by each tool. The known cleavage sites of the other caspases, which were positively predicted by CASVM or Cascleave, were not counted as false positives.