miREvo: an integrative microRNA evolutionary analysis platform for next-generation sequencing experiments

BMC Bioinformatics

Table 1 Comparison of computational tools for microRNA analysis

Feature	miROrtho[4]	miRNA-miner[21]	microHAR-VESTER[20]	miRanalyzer[18]	miRExpress[17]	miRDeep-P[9]	miRDeep2[22]	UEA sRNA toolkit[19]	miREvo
Next-generation sequencing technology support	×	×	×	√	√	√	√	√	√
Expression profiling	×	×	×	√	√	×	√	√	√
comparison of orthologous gene expression	×	×	×	×	×	×	×	×	√
Novel miRNA Prediction for plant/animal	Animal	Animal	×	Both	×	Plant	Animal	Both	Both
Stem-loop structure viewing	√	√	√	√	√	√	√	√	√
Homology searching in plant/animal kingdom	Animal	Animal	Plant	×	×	×	×	×	Both
evolutionary distance calculating	×	×	×	×	×	×	×	×	√
Multiple miRNAs queries support	×	×	5 sequences max	×	×	×	×	√	√
Standalone/Web-service	Web	Web	Web	Both	Standalone	Standalone	Standalone	Both	Standalone
GUI/CLI	GUI	GUI	GUI	Both	CLI	CLI	CLI	GUI	Both

√, with the feature; ×, without the feature; GUI, Graphical User Interface; CLI, Command Line Interface.

ISSN: 1471-2105