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Table 12 DoBi’s performance for proteins of benchmark v4.0 in unbound states

From: Protein-protein binding site identification by enumerating the configurations

Subseta Typeb No. of cases Succ Accd Cove M f V g
Rigid body Enzyme-Inhibitor 40 51.2 48.9 66.9 37.1 34.1
  Antibody-Antigen 22 50.0 51.0 67.8 24.0 14.6
  Others 59 32.2 37.3 63.5 39.9 36.9
  Subtotal 121 41.7 43.6 65.4 36.1 31.9
Medium difficult Enzyme-Inhibitor 7 39.9 36.7 56.2 25.9 17.4
  Antibody-Antigen 1 0 31.9 41.4 38.0 9.2
  Others 22 31.2 33.4 56.7 52.9 56.7
  Subtotal 30 31.6 34.1 56.7 46.1 45.9
Difficult Enzyme-Inhibitor 5 37.5 43.1 46.5 26.1 7.0
  Antibody-Antigen 2 0 29.5 54.6 27.3 17.5
  Others 18 10.5 30.5 54.8 54.9 44.8
  Subtotal 25 13.9 32.4 53.4 46.9 35.1
Overall   176 36.0 40.4 62.2 39.3 36.9
  1. aSubset is based on the magnitude of conformational change after binding.
  2. bType is based on the broad biochemical categories.
  3. cSuc (%) is the success rate of DoBi on the data set.
  4. dAcc (%) is the average accuracy of DoBi on the data set.
  5. eCov (%) is the average coverage of DoBi on the data set.
  6. fM is the average predicted size for DoBi on the data set.
  7. gV is the standard deviation of predicted size for DoBi on the data set.