Figure 10

Pairwise percentage identity distribution for new families. (A). Boxplot for pairwise percent distribution for 18 multi-member families of group HTH, the following are the family names 1. *Cro and Cro like 2. *Homeodomain 3. LacI repressor 4. Hin recombinase 5. *RAP1 6. *Iron Dependent repressor 7. *Transcription factor IIB/IIA 8. NarL transcription factor 9. *Tn5 Transposase 10. *MutS 11. *Tetracycline Repressor 12. Interferon regulatory factor 13. *Catabolite gene activator protein 14. Transcription factor 15. *Ets domain 16. *Z-α domain 17. *Forkhead TF 18. Transcription activator BMRR (B). Boxplot for pairwise percent distribution for 20* multi-member families of group Zinc co-ordinating, Zipper type, Other α-helix, β-sheet, β-hairpin/ribbon and Other. The following are the family names- 1. *Zinc-coordinating-β-β-α-zinc finger 2. *Zinc-coordinating-Nuclear Receptors 3. *Zinc-coordinating-Loop-sheet-helix 4. *Zinc-coordinating-gal4 5. *Zipper-type-bzip1 6. *Zipper-type-bzip2 7. *Zipper-type-Helix-loop-helix 8. 8Other α-helix -histone 9. *Other α-helix -Site specific recombinases 10. *Other α-helix -High mobility group 11. Other α-helix -MADS box 12. *Other α-helix -CUT domain 13. *β-sheet-TATA box-binding 14. *β-hairpin-MetJ repressor 15. β-hairpin-Tus replication terminator 16. *β-hairpin-Integration host factor 17. *β-hairpin-Hyperthermophile DNA-BP 18. *β –hairpin-Arc repressor 19. β-hairpin-Omega Repressor 20. *β-hairpin-SRA Domain 21. *Other-Ig fold like TF 22. *Other-Seq A*Total number of plots are 21 in Figure 9(B) as bzip1 and bzip2 boxplots are different but they are subfamilies of single Leucine zipper family (C). Boxplot for pairwise percent distribution for 43 multi-member families of group enzymes. The following are the family names- 1. Methyltransferase 2. Endonuclease PvuII 3. Endonuclease ecorV 4. *Endonuclease ecorI 5. Endonuclease BamHI 6. *Enonuclease V 7. *Dnase I 8. *HIV reverse transcriptase 9. *Uracil-DNA glycosylase 10. 3-Methyladenine DNA glycosylase 11. *Homing endonuclease 12. *Topoisomerase I 13. T7 RNA Pol 14. N4 RNA Pol 15. HincII restriction endonuclease 16. *Endonuclease III and MutY 17. *DNA Photolyase 18. α-glucosyl transferase 19. *Helicase 20. *Thymine DNA-glycosylase 21. 8-oxoguanine DNA glycosylase 22. ALKA 23. Phi 6 RNA Pol 24. β-Glucosyltransferase 25. *Endonuclease VIII and MutM 26. Human tyrosyl-DNA phosphodiesterase 27. Relaxase TrwC 28. *Nuclease-Colicin 29. Endonuclease IV 30. Excisionase (Xis) 31. ISHp608 Transposase 32. AlkB 33. Restriction Endonuclease HinP1I 34. ABH2 35. Restriction endonuclease SgrAI 36. *Family A Polymerases 37. *Family B Polymerases 38. *Family X Polymerases 39. *Family Y Polymerases 40. *DNA Ligase 41. *Family C polymerases 42. Mtaq 1 methylase 43.* DAM(Stars in front of the family name implies it has wide distribution of percent identity and further the family was subjected to Jack-knifing for selecting the representative)