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Figure 2 | BMC Bioinformatics

Figure 2

From: Optimal experiment selection for parameter estimation in biological differential equation models

Figure 2

Convergence criterion for minimization algorithm. The set of model predictions in data space form a surface known as the model manifold. By comparing the angle between the tangent plane to the Model Manifold and the vector of unfit data, we can monitor convergence to a local minimum of the cost. If αis approximately a right angle, then we are likely near a local minimum. Fits separated by more than |r(θ)|cosα are likely to correspond to different minima.

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