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Figure 3 | BMC Bioinformatics

Figure 3

From: Optimal experiment selection for parameter estimation in biological differential equation models

Figure 3

Cost barrier between two minima. Although we identified several distinct local minima with that were able to fit the data well, a direct line path connecting these minima reveal that the cost barrier between them is very small. Here we see two points for which the cost barrier between them is about 50. Most randomly selected parameter values have a cost between 1,000 and 10,000, illustrating that this barrier is relatively small. It is possible that these minima are not distinct but are connected by a winding canyon.

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