Table 1 Protein pairs ranked by the discriminability index scores
Protein 1 (upregulated in IPS progressors) | Protein 2 (downregulated in IPS progressors) | DI score | p-value | FDR rate |
|---|---|---|---|---|
APCS Serum amyloid P-component | HGFAC Hepatocyte growth factor activator | 2.01 | 0 | 0.00 |
C8G Complement component C8 gamma chain | HGFAC Hepatocyte growth factor activator | 1.60 | 1.6×10−6 | 0.01 |
APCS Serum amyloid P-component | CFHR1;LOC100293069 Complement factor H-related 1 | 1.58 | 1.6×10−6 | 0.01 |
C4BPA C4b-binding protein alpha chain | ENO2 Gamma-enolase | 1.48 | 6.3×10−6 | 0.01 |
C4BPA C4b-binding protein alpha chain | HGFAC Hepatocyte growth factor activator | 1.45 | 9.5×10−6 | 0.01 |
APOA4 Apolipoprotein A-IV | ALB Putative uncharacterized protein ALB | 1.44 | 9.5×10−6 | 0.01 |
APCS Serum amyloid P-component | CFHR2 Isoform Short of Complement factor H-related protein 2 | 1.43 | 1.1×10−6 | 0.01 |
F2 Prothrombin (Fragment) | HGFAC Hepatocyte growth factor activator | 1.37 | 3.5×10−6 | 0.03 |
APOD Apolipoprotein D | HGFAC Hepatocyte growth factor activator | 1.35 | 5.7×10−6 | 0.05 |
CPB2 Isoform 1 of Carboxypeptidase B2 | HGFAC Hepatocyte growth factor activator | 1.31 | 9.3×10−6 | 0.08 |
SERPINA6 Corticosteroid-binding globulin | HGFAC Hepatocyte growth factor activator | 1.30 | 9.8×10−6 | 0.09 |
APCS Serum amyloid P-component | F10 Coagulation factor X | 1.30 | 1.1×10−4 | 0.09 |
C8A Complement component C8 alpha chain | HGFAC Hepatocyte growth factor activator | 1.26 | 1.6×10−4 | 0.11 |
APOA4 Apolipoprotein A-IV | GPX3 Glutathione peroxidase 3 | 1.25 | 1.7×10−4 | 0.10 |
APOB Apolipoprotein B-100 | HGFAC Hepatocyte growth factor activator | 1.24 | 1.8×10−4 | 0.10 |
FGG Isoform Gamma-B of Fibrinogen gamma chain | AZGP1 alpha-2-glycoprotein 1, zinc” | 1.23 | 2.0×10−4 | 0.10 |
AGT Angiotensinogen | HGFAC Hepatocyte growth factor activator | 1.22 | 2.1×10−4 | 0.10 |
APCS Serum amyloid P-component | ENO2 Gamma-enolase | 1.18 | 2.8×10−4 | 0.13 |
CPB2 Isoform 1 of Carboxypeptidase B2 | C1QC Complement C1q subcomponent subunit C | 1.17 | 2.9×10−4 | 0.12 |
APCS Serum amyloid P-component | GPX3 Glutathione peroxidase 3 | 1.17 | 3.0×10−4 | 0.11 |
C4BPA C4b-binding protein alpha chain | LBP Lipopolysaccharide-binding protein | 1.16 | 3.0×10−4 | 0.11 |
APCS Serum amyloid P-component | LOC653879 similar to complement component 3 | 1.15 | 3.3×10−4 | 0.11 |
CPB2 Isoform 1 of Carboxypeptidase B2 | AFM Afamin | 1.15 | 3.3×10−4 | 0.10 |