Figure 6

CLAG on a coevolution scores matrix. Clustering of the MST matrix of coevolution scores for the globin protein family [19]. It is a squared matrix on 67 alignment positions selected by the MST method as susceptible to coevolve. A: Slices of the clusterized matrix associated to all key aggregates obtained with Δ = 0.2, and environmental and symmetric scores ≥ 0.5. The order of the 67 positions in the y-axis follows the order of the key aggregates positions in the x-axis (from left to right). Positions belonging to key aggregates obtained for Δ = 0.1,0.2,0.3with environmental and symmetric scores = 1are reported at the bottom of the matrix with the help of colored bars. For Δ = 0.1,0.3and Δ = 0.2(bottom), the score of aggregation is = 1. For Δ = 0.2(top), scores are ≥ 0.5. Key aggregates obtained without considering the symmetricity condition in CLAG are reported (bottom) for Δ = 0.2and environmental scores = 1. B: hierarchical clustering of the dataset where key aggregates of Δ = 0.2and scores ≥ 0.5detected in A are highlighted (colors as in A).