Table 3 Pathway analysis performed using SPIA statistical test on graphite networks.
From: graphite - a Bioconductor package to convert pathway topology to gene network
Name | FDR | Signal | Database | BCR | ABL | |
|---|---|---|---|---|---|---|
1 | Leishmaniasis | 0.03 | Activated | KEGG | ||
2 | Phase 1 - Functionalization of compounds | 0.02 | Activated | Reactome | ||
3 | Syndecan-4-mediated signaling events | 0.00 | Activated | NCI | ||
4 | Regulation of RAC1 activity | 0.00 | Activated | NCI | ||
5 | RAC1 signaling pathway | 0.00 | Activated | NCI | ||
6 | RhoA signaling pathway | 0.00 | Activated | NCI | ||
7 | Regulation of RhoA activity | 0.00 | Activated | NCI | ||
8 | Noncanonical Wnt signaling pathway | 0.00 | Activated | NCI | ||
9 | Wnt signaling network | 0.00 | Activated | NCI | ||
10 | BCR signaling pathway | 0.00 | Inhibited | NCI | ||
11 | IL6-mediated signaling events | 0.00 | Inhibited | NCI | ||
12 | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | 0.00 | Inhibited | NCI | ||
13 | Stabilization and expansion of the E-cadherin adherens junction | 0.00 | Activated | NCI | ||
14 | E-cadherin signaling in the nascent adherens junction | 0.00 | Activated | NCI | ||
15 | E-cadherin signaling events | 0.00 | Activated | NCI | ||
16 | HIF-1-alpha transcription factor network | 0.00 | Inhibited | NCI | ||
17 | ALK1 signaling events | 0.01 | Activated | NCI | ||
18 | Canonical Wnt signaling pathway | 0.02 | Activated | NCI | ||
19 | ALK1 pathway | 0.02 | Activated | NCI | ||
20 | S1P2 pathway | 0.02 | Inhibited | NCI | ||
21 | Regulation of nuclear SMAD2/3 signaling | 0.02 | Activated | NCI | ||
22 | Regulation of cytoplasmic and nuclear SMAD2/3 signaling | 0.02 | Activated | NCI | ||
23 | TGF-beta receptor signaling | 0.02 | Activated | NCI | ||
24 | C-MYB transcription factor network | 0.02 | Activated | NCI | ||
25 | Osteopontin-mediated events | 0.02 | Inhibited | NCI | ||
26 | Direct p53 effectors | 0.02 | Inhibited | NCI | ||
27 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | 0.03 | Activated | NCI | ||
28 | Regulation of nuclear beta catenin signaling and target gene transcription | 0.03 | Activated | NCI | ||
29 | S1P4 pathway | 0.03 | Inhibited | NCI | ||
30 | amb2 Integrin signaling | 0.03 | Activated | NCI | ||
31 | p38 MAPK signaling pathway | 0.04 | Activated | NCI | ||
32 | Posttranslational regulation of adherens junction stability and dissassembly | 0.04 | Activated | NCI | ||
33 | N-cadherin signaling events | 0.04 | Activated | NCI | ||
34 | Lissencephaly gene (LIS1) in neuronal migration and development | 0.05 | Activated | NCI | ✓ | |
35 | C-MYC pathway | 0.06 | Inhibited | NCI | ||
36 | p53 pathway | 0.06 | Activated | NCI |