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Table 9 11 sequence similarity descriptors of HDAC2, 4, 6, 7 and 8

From: Screening of selective histone deacetylase inhibitors by proteochemometric modeling

  Class I     Class IIa     Class IIb   Class IV
  HDAC1 HDAC2 HDAC3 HDAC8 HDAC4 HDAC5 HDAC7 HDAC9 HDAC6 HDAC10 HDAC11
Class I
HDAC2 85.1 100.0 51.9 30.7 10.2 9.6 9.7 9.9 9.4 14.2 18.9
HDAC8 30.8 30.7 34.4 100.0 9.0 8.4 9.9 10.8 8.1 13.6 21.4
Class IIa
HDAC4 11.1 10.2 9.5 9.0 100.0 58.4 46.9 54.3 20.6 11.1 8.6
HDAC7 10.0 9.7 10.5 9.9 46.9 40.5 100.0 39.7 19.1 13.0 9.6
Class IIb
HDAC6 9.5 9.4 7.7 8.1 20.6 17.2 19.1 16.6 100.0 23.4 7.4
  1. For all possible HDACs pairs, sequence identities (in %) are reported.