Table 9 11 sequence similarity descriptors of HDAC2, 4, 6, 7 and 8
From: Screening of selective histone deacetylase inhibitors by proteochemometric modeling
| Â | Class I | Â | Â | Â | Class IIa | Â | Â | Â | Class IIb | Â | Class IV |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | HDAC1 | HDAC2 | HDAC3 | HDAC8 | HDAC4 | HDAC5 | HDAC7 | HDAC9 | HDAC6 | HDAC10 | HDAC11 |
Class I | |||||||||||
HDAC2 | 85.1 | 100.0 | 51.9 | 30.7 | 10.2 | 9.6 | 9.7 | 9.9 | 9.4 | 14.2 | 18.9 |
HDAC8 | 30.8 | 30.7 | 34.4 | 100.0 | 9.0 | 8.4 | 9.9 | 10.8 | 8.1 | 13.6 | 21.4 |
Class IIa | |||||||||||
HDAC4 | 11.1 | 10.2 | 9.5 | 9.0 | 100.0 | 58.4 | 46.9 | 54.3 | 20.6 | 11.1 | 8.6 |
HDAC7 | 10.0 | 9.7 | 10.5 | 9.9 | 46.9 | 40.5 | 100.0 | 39.7 | 19.1 | 13.0 | 9.6 |
Class IIb | |||||||||||
HDAC6 | 9.5 | 9.4 | 7.7 | 8.1 | 20.6 | 17.2 | 19.1 | 16.6 | 100.0 | 23.4 | 7.4 |