CMF -significant residue positions are in contact with gefitinib binding sites in human EGFR protein (PDB-Entry 2J6M). Yellow spheres denote positions of the gefitinib binding sites in the wild type kinase. Blue spheres show the localization of significant adjacent residue positions found by CMF which are in contact with these binding sites. Moreover, the CMF-significant sites I759, Y764, M766 and K846, shown with green spheres, are already described as nsSNP positions and they are also in contact with gefitinib binding sites E762 and M793, respectively. The circles indicate clusters of gefitinib binding sites and their significant adjacent sites.