Figure 4

CMF -significant residue positions are in contact with glucose binding site and allosteric site in human GCK protein (PDB-Entry 1V4S). (A) Yellow spheres show the structural positions of the glucose binding sites (active sites). Blue spheres correspond to localization of significant adjacent residue positions found by CMF which are in contact with these active sites. (B) Orange spheres denote the allosteric sites. Blue spheres correspond to localization of just significant adjacent residue positions and green spheres indicate the significant residue positions which are already described as nsSNP position and in contact with these allosteric site. Additionally, the significant position R63 is allosteric site by itself and it is also in contact with an other allosteric site. The circles indicate clusters of glucose binding sites (A), allosteric sites (B), and their significant adjacent sites.