Coupled mutation finder: A new entropy-based method quantifying phylogenetic noise for the detection of compensatory mutations

Table 1 CMF-significant essential sites in human EGFR protein, which are nearby either nsSNPs or strictly conserved sites

*CMF*-significantessential sites	Nearby nsSNPs, or strictlyconserved sites	Reference
Y727	726^c 743^c	-
H 755	756^s, 758^s	[35]
D 800	798^c	-
G 824	773^s	[35]
D 830	829^s	[35]
E 868	892^s	[35]
E 872	873^s	[34]
V 876	877^c	-
K 879	877^c, 880^c	-
Y 891	892^s, 895^c	[35]
S 899	880^c, 896^c, 898^c, 901^c	-
Y 900	898^c, 901^c	-
T 909	906^c, 936^c	-
S 912	906^c, 936^c	-
K 913	914^c	-
D 916	914^c	-
M 947	901^c, 950^c	-

ISSN: 1471-2105