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Table 2 CMF-significant essential sites in human GCK protein, which are nearby either nsSNPs or strictly conserved sites

From: Coupled mutation finder: A new entropy-based method quantifying phylogenetic noise for the detection of compensatory mutations

CMF-significant essential sites Nearby nsSNPs or strictly conserved sites Reference
M34 36s [34]
T 65 66c  
E 67 66c, 68c -
T 82 81c -
N 83 81c, 108s, 110s [34]
H 105 106s [29]
C 129 131s, 132s [29, 34]
F 133 131s, 132s [29, 34]
F 148 147c, 150c,s [34]
F 152 150c,s, 151c [34]
H 156 162s [29]
N 180 162s, 182s [29, 34]
F 260 257s, 258c, 259s, 261s [34]
D 262 259s, 261s, 264s [34, 42]
L 266 261s, 264s, 265s [29, 34, 42]
D 267 264s, 265s [29, 42]
L 271 274c -
S 281 278c, 279s [34]
Q 286 259s [34]
E 331 299c,s [34]
T 332 295c, 299c,s [34]
R 333 336s [34]
Q 337 336s [34]
E 339 336s [34]
N 391 392s [29, 34]
S 411 227c,s, 410c, 414s [34]
S 418 416s [30]
F 419 416s [30]
E 442 444c -
E 443 444c, 445c -
  1. s: non-synonymous snp site,c: strictly conserved site.