Coupled mutation finder: A new entropy-based method quantifying phylogenetic noise for the detection of compensatory mutations

Table 2 CMF-significant essential sites in human GCK protein, which are nearby either nsSNPs or strictly conserved sites

*CMF*-significant essential sites	Nearby nsSNPs or strictly conserved sites	Reference
M34	36^s	[34]
T 65	66^c
E 67	66^c, 68^c	-
T 82	81^c	-
N 83	81^c, 108^s, 110^s	[34]
H 105	106^s	[29]
C 129	131^s, 132^s	[29, 34]
F 133	131^s, 132^s	[29, 34]
F 148	147^c, 150^c,s	[34]
F 152	150^c,s, 151^c	[34]
H 156	162^s	[29]
N 180	162^s, 182^s	[29, 34]
F 260	257^s, 258^c, 259^s, 261^s	[34]
D 262	259^s, 261^s, 264^s	[34, 42]
L 266	261^s, 264^s, 265^s	[29, 34, 42]
D 267	264^s, 265^s	[29, 42]
L 271	274^c	-
S 281	278^c, 279^s	[34]
Q 286	259^s	[34]
E 331	299^c,s	[34]
T 332	295^c, 299^c,s	[34]
R 333	336^s	[34]
Q 337	336^s	[34]
E 339	336^s	[34]
N 391	392^s	[29, 34]
S 411	227^c,s, 410^c, 414^s	[34]
S 418	416^s	[30]
F 419	416^s	[30]
E 442	444^c	-
E 443	444^c, 445^c	-

ISSN: 1471-2105