From: Network enrichment analysis: extension of gene-set enrichment analysis to gene networks
Functional gene set | FNEA (kā=ā 100) | MNEA | GEA (kā=ā 100) | GSEA |
---|---|---|---|---|
Ding et al., 2008 | ||||
āAll (623 genes) | 66 | 114 | 1 | 102 |
āDrivers (26) | 74 | 95 | 21 | 16 |
āMutated ā¤1 (153) | 39 | 102 | 2 | 75 |
COSMIC | ||||
āDetected >1 (110) | 34 | 33 | 22 | 30 |
āDetected once (median)ā (110) | 18 | 52 | 9 | 28.5 |
KEGG05223 non-small cell lung cancer (56) | 48 | 99 | 2 | 40 |
Largest contrast GEA > FNEA | ||||
āKEGG00362 Benzoate degradation via hydroxylation (3) | 4 | 27 | 123 | 31 |
āKEGG00513 High-mannose type N-glycan biosynthesis (4) | 2 | 5 | 123 | 24 |
āKEGG00780 Biotin metabolism (4) | 1 | 13 | 123 | 11 |
āKEGG00300 Lysine biosynthesis (5) | 0 | 6 | 123 | 34 |
āKEGG00785 Lipoic acid metabolism (4) | 0 | 2 | 123 | 18 |
Largest contrast FNEA > GEA | ||||
āGO0001666 Response to hypoxia (163) | 119 | 114 | 11 | 105 |
āKEGG05200 Pathways in cancer (254) | 112 | 118 | 6 | 99 |
āGO0001525 Angiogenesis (129) | 115 | 113 | 10 | 118 |
āKEGG04010 MAPK signaling pathway (286) | 107 | 114 | 4 | 82 |
āKEGG04020 Calcium signaling pathway (183) | 99 | 108 | 5 | 60 |