Figure 4

Proxy meta-analysis schematic example. Schematic example of a meta-analysis with proxy markers. For simplicity we consider only two studies with four markers each (1-4). Common MA is applied on markers 1 and 4 (as they are present in both marker sets), yet when YAMAS hits marker 3, which is missing in the second study (3 – gray box), it selects marker 2 in study 2 as its proxy marker, based on the r² indicator. Dashed arrows indicate non-chosen potential proxy markers. The case of the missing marker 2 in study 1 is omitted for better readability.