Figure 5

Shabtai et al. Four correlation score distribution outcome of TAG4 Microarray dataset. The BE algorithm is least affected by the experiment date and most affected by experiment’s chemical compound used. The graphs show the distribution of scores. The graphs on the left column represent results affected by date (a, c, e, g). The solid blue line represents the score distribution of experiment pairs performed on identical dates, and the fragmented red line represents the score distribution of experiment pairs performed on different dates (a, c, e, g). The distributions according to date are significantly diverse for Pearson, Spearman and Kendall correlations (a, c, e), whereas the distributions by date are similar for BE correlation (g), meaning the scores were highly comparable for experiments done on the same date compared to experiments done on different dates. The graphs on the right column represent the score distributions affected by chemical compound (b, d, f, h). The solid blue line represents the score distribution of experiment pairs using identical chemical compounds, and the fragmented red line represents the score distribution of experiment pairs using different chemical compounds. All methods show that the distribution of the same chemical compound scores is significantly different than the distribution of different chemical compound scores, signifying, as expected, that all methods are affected by the chemical compound. The BE method shows the most significant difference in distribution compared to the other methods (h), being most affected by the chemical compound.