MeSHOP for “Computational Biology”. MeSHOPs were generated for the 50 most recent articles annotated with the MeSH term “Computational Biology” from the year 1999 (A) and the year 2008 (B). MeSHOPs were computed using the universal background from PubMed Baseline 2011 (covering articles through 2010). The MeSH term for “Computational Biology” and its parent terms were excluded from the MeSHOP. (C) Change in Significance of Biomedical Terms for Computational Biology over Time. The p-values for the terms “Biochemistry” and “Information Services” and their association to “Computational Biology” over time. For each time point, a MeSHOP using the most recent 50 articles for that year was generated to obtain the p-values for the terms.