Skip to main content

Table 5 CrmMiner performance on 57 human tissues and cell types

From: Predicting tissue specific cis-regulatory modules in the human genome using pairs of co-occurring motifs

Tissue

E-value h

P-value

Pairs

The Three Most Enriched Pairs

subthalamic nucleus

6.72

2.1e −10

78

E2F1-TFIII E2F1DP2-ZBED6 GAF-NFMUE1

prefrontal cortex

6.60

5.7e −15

58

SP1-PITX3 PAX4-BEN EFC-E2A

cingulate cortex

6.44

4.3e −13

37

MAZR-NFAT2 PAX9-IK3 HEB-AHRARNT

heart

5.52

4.4e −20

89

PAX9-PXRRXR RSRFC4-E47 CETS1P54-NRSE

caudate nucleus

5.27

5.6e −14

20

SP1SP3-SP1 SP1-ETF MZF1-TAXCREB

prostate

5.03

4.2e −8

79

E2F-UF1H3BETA NFY-AP2GAMMA MSX3-SP3

amygdala

4.61

7.3e −10

34

ZFP281-RFX AHR-CKROX ETF-SP4

BM-CD71+ early erythroid

4.56

1.5e −8

90

PAX4-NRF1 NFY-KROX MOVOB-NFAT2

adrenal gland

4.40

5.7e −7

71

STAT6-ZF5 SP1-GATA3 NKX11-SP4

fetal brain

4.26

5.2e −15

90

VDR-E2F1 OBOX2-PPARA BEN-ETF

bone marrow

4.16

1.8e −7

68

CDXA-SP1 NFKB-E2F1 AR-PR

BM CD34+

4.15

6.0e −9

130

NRSE-E2F1 E2F1-SP1 E2F-SP1

fetal thyroid

4.13

5.3e −8

108

E2F-SP4 NFY-ZF5 STAT3-MEF2

bronchial epithelial cells

4.09

7.4e −7

85

HOXD3-CEBP KLF15-CEBP NKX25-HEN1

occipital lobe

4.09

6.4e −4

38

EGR2-DEAF1 AHR-CACCCBINDINGFACTOR E2F1-SREBP

whole brain

4.05

3.5e −12

21

MAZ-ETF SP1SP3-GKLF MZF1-CTCF

PB-BDCA4+ dentritic cells

4.04

2.3e −9

98

ATF1-ETF AP1-PEBP AP2-PPARA 1

placenta

3.82

1.6e −11

96

COMP1-GKLF GKLF-NFY CTCF-AP1

hypothalamus

3.82

5.3e −5

80

GADP-ERR1 AP1-FOXO1 OCT-PAX5

liver

3.73

5.7e −9

97

COUP-SZF11 COUPTF-SRF GATA4-GFI1

thyroid

3.65

8.6e −8

93

MTATA-OLF1 MUSCLE-CHX10 LBX2-SP4

thymus

3.65

5.0e −7

93

IK1-KLF15 MINI19-ALPHACP1 IK1-GKLF

spinal cord

3.64

1.5e −6

68

IRF-LRF REX1-GLI3 ALPHACP1-PPARA

uterus

3.58

2.9e −8

85

ELK1-UF1H3BETA TAL1-E2F1 AP2ALPHA-PITX1

pons

3.57

6.1e −5

108

IPF1-CART1 NMYC-CNOT3 PAX4-MYOGNF1

trachea

3.48

1.1e −9

110

TRF1-TFIII DEC-CP2 COUPTF-STAT4

lung

3.47

3.0e −7

36

AP2-TR4 MAZ-CBF SP1SP3-AP1

tonsil

3.42

0.0019

60

HEN1-NFKAPPAB65 PAX4-SMAD E2F6-NRSF

PB-CD19+ Bcells

3.40

9.5e −8

61

ESE1-PAX6 PAX4-TBX5 MZF1-NRF2

721 B lymphoblasts

3.35

1.8e −6

104

SP1SP3-E2F4DP1 STAT4-NRF2 ZIC1-EGR1

testis

3.30

4.8e −4

73

AP2-ATF T3R-HNF4 MYOD-SRF

uterus corpus

3.27

1.3e −8

91

TCF4-POU6F1 CAAT-PITX3 PAX4-XVENT1

tongue

3.24

3.8e −7

72

ZFP281-NFY SP3-PITX3 AP2-IK2

temporal lobe

3.21

3.7e −7

95

TBX5-MTF1 MTATA-HIC1 ERG-ZIC3

PB-CD56+ NKCells

3.12

3.1e −5

53

NFY-SP1 CMYB-STAT6 SRF-SP4

smooth muscle

3.11

2.9e −6

87

KROX-MEF2 SP1-XBP1 HIF1-IK

pituitary gland

3.06

2.2e −6

96

MTATA-MAZR ZF5-WT1 AHR-ETF

adrenal cortex

3.04

1.5e −5

111

MYCMAX-PAX4 SP2-E2F1 VJUN-ZNF219

BM-CD105+ endothelial

2.95

0.0049

79

E2F-SMAD4 AP4-PAX4 P53-NFY

lymph node

2.94

2.6e −5

131

CETS1P54-GABP HIF1-NRSE PEA3-MTF1

adipocyte

2.91

1.3e −6

79

AP2-NFY E2F1-LXR CNOT3-IK2

skeletal muscle

2.89

7.6e −7

80

P53-CACD MEIS2-STAT1 MYOD-XVENT1

thalamus

2.86

0.0065

42

PLAG1-PAX3 AP1-CMAF MZF1-GATA2

pancreatic islets

2.79

6.7e −8

97

CDXA-PROP1 MEIS1-ZBED6 NFKB-E2F

skin

2.79

7.8e −5

73

CACBINDINGPROTEIN-XVENT1 NFKB-ZTA ER-SREBP1

medulla oblongata

2.78

7.9e −7

103

ZNF515-NKX25 CETS1P54-NKX26 P53-CMYB

whole blood

2.77

5.8e −5

53

PU1-SP2 GFI1-CTCF AP2-GR

cardiac myocytes

2.69

9.1e −4

120

EGR-MECP2 SRY-CNOT3 E2F-EGR3

fetal lung

2.62

1.7e −4

55

HIF1-LMAF CTCF-MECP2 AML2-CP2

PB-CD4+ Tcells

2.58

0.0026

121

NGFIC-EGR3 ZFP206-CBF AHRARNT- COUP

cerebellum peduncles

2.52

1.2e −4

74

ZNF219-NFY KLF15-OBOX2 NKX11-ZNF219

olfactory bulb

2.31

4.3e −4

70

NFY-SP1 NFKAPPAB-CTCF CP2-GLI

cerebellum

2.30

0.0034

58

AP2-LBX2 COUPTF-E2F E2F-SREBP

kidney

2.29

4.08e −5

87

GCM-ARP1 E2A-RORBETA NFY-TFIII

BM-CD33+ myeloid

1.80

0.0489

92

SRF-HMGIY PR-STAT6 T3R-AP1

parietal lobe

1.78

0.0443

82

AP2ALPHA-E2F1 HIF1-GABP BEN-MYF

appendix

1.75

0.0285

88

AP1-LXR PAX2-PAX4 CNOT3-CREB

  1. We trained, validated and tested CrmMiner on 72 human tissues and cell types [36]. The mixed sets consisted of CNEs in the vicinity of 160 tissue-specific genes. Those CNEs were located within 10 kbp up or downstream of the TSSs, or were among the closest 20 CNEs to the TSSs. Here, we report CrmMiner performance on the testing sets. The number of motif pairs comprising the tissue-specific signatures are listed under the Pairs column. The P-values were obtained by one-tailed Fisher's exact test.