|
1
|
ir.res_ir=0
| |
|
2
|
grb2.res_grb2=0
|
set basal activity of insulin receptor, Grb2 or Shc to 0, i.e. remove respective species from the system
|
|
3
|
shc.res_shc=0
| |
|
4
|
ins.b1=0
|
prevent insulin binding to its receptor by blocking the binding site on insulin or by blocking both
|
|
5
|
ir.b_ins=0, ir.b_ins2=0
|
binding sites on the receptor
|
|
6
|
shc.b_ir=0
|
prevent Shc binding to insulin receptor by blocking the binding site on Shc or by preventing the
|
|
7
|
ir.p1=0
|
necessary phosphorylation of the receptor
|
|
8
|
grb2.b_shc=0
|
prevent Grb2 binding to Shc by blocking the binding site on Grb2 or by preventing the
|
|
9
|
shc.p1=0
|
necessary phosphorylation of Shc
|
