Figure 4

The Hox cluster in the UCSC Genome Browser. (http://genome.ucsc.edu/) A custom track of the TNS is displayed in full mode and in dense mode alongside the following publicly available tracks: predicted Ensembl genes, Human proteins mapped using tBLASTn, median gene expression from the Microarray Atlas data set, and chain/net tracks that indicate evolutionary conservation of genome sequence assembly with the genomes of other organisms. The TNS track was computed as follows: for each gene, the “best” associated TNS was identified and plotted. The “best” associated TNS is the maximum TNS of all gene neighborhoods that contain the gene. Note that gene expression is not well-correlated between members of the Hox cluster, while regional synteny is maintained in the mammalian genomes studied.