Figure 1

A) Schematic representation of information and interoperability loss across various stages of communication (from top to bottom). In the first tier, the trapezoids or cones represent different studies, while the complex shapes (circles + triangles) shown in various colors represent the parallel observations derived at the analyses level across each study. The input and output at each tier is indicated at the left and right respectively. The individual shapes (triangles and circles) in the second tier denote the partial and heterogeneous representation of information carried over to the publication level from the respective analyses of each study. Further changes taking place is reflected in the shapes in the third tier and represent the reduced and incompatible data across each study curated from the literature. Information and interoperability loss is indicated by the grey triangle on the left. The double-headed green arrows and red blocks indicate the compatibility status. B) Schematic representation of the steps (from left to right) in the GFML workflow. 1 & 2: Identification of key components and features of NGS gene fusion analyses from literature evidence and database curation not readily compatible, 3: Element and attribute standardization, 4 & 5: Implementation of XML Schema. Double-headed green arrows and red blocks indicate the compatibility status.