Glyceraldehyde 3-phosphate dehydrogenase. Predicted pockets and ligands on Thermoproteus tenax glyceraldehyde 3-phosphate dehydrogenase (TtGAPN). Only a single protein monomer is shown ([PDB:1UXR]). NADPH at the active site and activator fructose-6-phosphate (F6P) at the allosteric site are shown in ‘sticks’ representation, while residues in red correspond to the CSA active site annotations. Predicted pockets (geometric centers) are shown in ‘spheres’ representation, the pocket in orange color affected protein flexibility significantly according to our simulations, while yellow did not.