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Figure 3 | BMC Bioinformatics

Figure 3

From: Exploiting protein flexibility to predict the location of allosteric sites

Figure 3

Glyceraldehyde 3-phosphate dehydrogenase. Predicted pockets and ligands on Thermoproteus tenax glyceraldehyde 3-phosphate dehydrogenase (TtGAPN). Only a single protein monomer is shown ([PDB:1UXR]). NADPH at the active site and activator fructose-6-phosphate (F6P) at the allosteric site are shown in ‘sticks’ representation, while residues in red correspond to the CSA[21] active site annotations. Predicted pockets (geometric centers) are shown in ‘spheres’ representation, the pocket in orange color affected protein flexibility significantly according to our simulations, while yellow did not.

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