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Figure 2 | BMC Bioinformatics

Figure 2

From: Simple binary segmentation frameworks for identifying variation in DNA copy number

Figure 2

Our analysis of the breast cancer S1514. The borders between chromosomes are represented by vertical bars. The red lines indicate the mean values among the probes in segments obtained by the proposed procedure. As we increase the value of τ+, higher-level gains are readily identifiable. (a) For τ+ = 0.2, we identified single-copy duplication at the end of chromosomes 3 and 11. We identified double-copy duplication at the beginning of chromosome 5 and single-copy duplication in the remaining region of chromosome 5. We also identified very high-level amplification from the center to the end of chromosome 20. (b) For τ+ = 0.3, we found single-copy duplication from the center to the end of chromosome 3. We identified double-copy duplication at the beginning of chromosome 5 and single-copy duplication in the remaining region of chromosome 5. We also identified very high-level amplification from the center to the end of chromosome 20. We did not identify alternations on chromosome 11, due to low-level amplified signals. (c) For τ+ = 0.5, we identified double-copy duplication in the center of chromosome 20. At the end of chromosome 20, we identified very high-level gain (more than triple-copy). We identified double-copy duplication at the beginning of chromosome 5 and single-copy duplication in the remaining region of chromosome 5. We did not identify alternations on chromosomes 3 and 11, due to low-level amplified signals.

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