Figure 2

Correlation between alignment accuracy and the fraction of common contacts (FCC). The Cβ-Cβ distance with cutoff 6.5Å was used to define residue contact since it demonstrated one of the best fold recognition accuracies. For each pair of proteins of the same fold, the FCC is plotted relative to the alignment sensitivity, which is defined as the fraction of the correctly aligned residue pairs by A, HHpred; B, SUPRB; among the residue pairs aligned in the correct alignment by TM-Align