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Table 8 Drug target distribution in different pathway databases

From: Effects of protein interaction data integration, representation and reliability on the use of network properties for drug target prediction

Database

#drug target in database

#Non-drug target in database

% of proteins in database that are drug targets

% of all drug targets with pathway info

% of all non-drug targets with pathway info

UniProt (all prots)

1953

113741

1.69

83.97

8.33

PID

394

1261

23.81

20.17

1.11

Reactome

1262

4215

23.04

64.62

3.71

KEGG

1414

7473

15.91

72.40

6.57

  1. 84% of all drug-targets under study have pathway information. KEGG includes the highest number of drug targets (72%), followed by Reactome (65%). The number of non-drug targets in each database is small compared to all non-drug targets in UniProt, suggesting that pathways might be enriched for drug targets. Only 1.69% of UniProt proteins are drug targets while they constitute 15.9%-23.8% of pathway databases. This observation is confirmed by comparing the percentages of drug targets and non-drug targets in UniProt to those per database: KEGG, for example, contains 72.4% of all drug targets but only 6.6% of all non-drug targets found in UniProt.