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Table 1 List of proteins with human-specific ubiquitylation sites

From: Gains of ubiquitylation sites in highly conserved proteins in the human lineage

Noa

Protein

IPI accession

Modification siteb

Positionc

Experimentd

Title

38

CASC5

IPI00163659.6

QMHVSLK EDENNS

262

Kim

cancer susceptibility candidate 5

49

CIAPIN1

IPI00387130

VSVENIK QLLQSA

48

Wagner

cytokine induced apoptosis inhibitor 1

67

DSC3

IPI00031549

SGRGVDK EPLNLF

180

Wagner

desmocollin 3

75

ERCC2

IPI00442420.2

ESEETLK RIEQIA

701

Kim

excision repair cross-complementing rodent repair deficiency, complementation group 2

82

FANCA

IPI00006170.2

GRSLELK GQGNPV

1387

Kim

Fanconi anemia, complementation group A

118

KIAA1731

IPI00400986.6

SGTIASK ERTLSS

435

Kim

KIAA1731

150

MYO6

IPI00844172.1

AQLARQK EEESQQ

993

Kim

myosin VI

155

NBR1

IPI00299920.5

ERGAEGK PGVEAG

435

Kim

neighbor of BRCA1 gene 1

156

NCAPD2

IPI00299524.1

RGLDGIK ELEIGQ

1301

Kim, Wagner

non-SMC condensin I complex, subunit D2

214

SCO2

IPI00014458

GLTGSTK QVAQAS

196

Wagner

SCO cytochrome oxidase deficient homolog 2 (yeast)

215

SDR42E1

IPI00163504.4

LNRNLIK EVNVRG

96

Kim

short chain dehydrogenase/reductase family 42E, member 1

234

SLX4

IPI00291796.2

SDPLEEK KALEIS

1179

Kim

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

259

TRMT6

IPI00099311

HGTFSAK MLSSEP

273

Wagner

tRNA methyltransferase 6 homolog (S. cerevisiae)

  1. aThe number corresponds to that in Additional file 1 and in Additional file 2.
  2. bThe ubiquitylated lysine is in bold.
  3. cThe positions are based on the International Protein Index (IPI) records and may differ from those of the UniProt or NCBI Protein records.
  4. dExperimental evidence for modifications: Kim, Kim et al.[22]; Wagner, Wagner et al.[24].