Multiple-platform data integration method with application to combined analysis of microarray and proteomic data

BMC Bioinformatics

Table 6 Additional simulations

Method	Multi-plat	1st ind.	2nd ind.
Scenario 1:	Extremely small sample size
	two measurements from each group
PSR Mean	0.3022	0.2363	0.2179
PSR Var	0.0009	0.0006	0.0007
FDR Mean	0.3782	0.4436	0.4694
FDR Var	0.0023	0.0025	0.0027
Scenario 2:	Correlation among platforms set to 0.5
	Disease and normal groups are independent
PSR Mean	0.6689	0.5365	0.5578
PSR Var	0.0009	0.0008	0.0011
FDR Mean	0.2255	0.2690	0.2641
FDR Var	0.0008	0.0010	0.0010
Scenario 3:	Non-standardized version of t_m and t_p
	i.e. t_m = $\bar{x_{2}} - \bar{x_{1}}$ , t_p = $\bar{y_{2}} - \bar{y_{1}}$
PSR Mean	0.8142	0.5479	0.5992
PSR Var	0.0009	0.0005	0.0010
FDR Mean	0.1586	0.2358	0.2235
FDR Var	0.0006	0.0011	0.0010

ISSN: 1471-2105