Generalization of the normal-exponential model: exploration of a more accurate parametrisation for the signal distribution on Illumina BeadArrays

Table 4 Excess risk ratio of background corrected raw-scale intensities

μ,σ,k,θ	R(1)	R(2)	R(3)	R(4)	R(5)	MAD $({\hat{S}}^{(0)})$
set 1	1.00	4.16	1.77	1.52	1.16	2.34
set 2	1.00	4.10	1.90	1.66	1.20	11.7
set 3	1.00	1.00	4.69	1.00	1.00	4.57
set 4	1.00	1.00	3.71	1.00	1.02	31.4
set 5	1.00	1.00	2.11	1.00	1.15	2.95
set 6	1.00	1.00	1.46	1.00	1.35	17.2

Mean Absolute Deviation (MAD) of the background corrected intensities for methods ${\hat{S}}^{(j)}$ , j=1,…,5 divided by the MAD for the theoretical normal-gamma BgC with the true parameters (method ${\hat{S}}^{(0)}$ ), from the simulation data set (S₁). Column 1: normal-gamma, column 2: normexp-MLE, column 3: normexp-RMA, column 4: normexp-NP, column 5: background subtraction. The MAD of the theoretical normal-gamma deconvolution with the true parameters is given as reference in column 6.

ISSN: 1471-2105