The proportion of correctly annotated BLAST hits in the SWISS-PROT dataset. The mean of proportions of BLAST hits with function descriptions similar to those of their query sequences was recorded before (grey bars) and after (brown bars) the removal of circular referencing. Statistics was computed using all GO terms (darker bars) and by accepting only GO terms with experimental or computational evidence codes (lighter bars). BLAST hits were selected based on DE annotation, GO annotation, GO or DE annotation, GO and DE annotation, and BLANNOTATOR. The reported means were calculated over all test protein sequences.