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Table 3 Accordance with prior knowledge

From: PPINGUIN: Peptide Profiling Guided Identification of Proteins improves quantitation of iTRAQ ratios

Protein ID

Description

log2Fold

P-Value

#Peptides

X!Tandem Score

Q9Z204

heterogeneous nuclear ribonucleoprotein C

1.21

0.158

2

2.8

O35490

betaine-homocysteine methyltransferase

-0.979

0.00148

24

59.6

P33267

cytochrome P450, family 2, subfamily f*

-0.857

0.131

3

10.1

P97872

flavin containing monooxygenase 5

-0.799

0.0425

3

10.6

Q91V92

ATP citrate lyase*

0.72

0.231

5

9.4

Q9Z2V4

phosphoenolpyruvate carboxykinase 1*

-0.706

0.0782

2

6.8

Q8VCH0

acetyl-Coenzyme A acyltransferase 1B

0.693

0.0318

2

6.1

P10649

glutathione S-transferase, mu 1*

-0.689

0.105

5

8.3

P01942

hemoglobin alpha, adult chain 1

0.678

0.359

16

16.2

P70694

aldo-keto reductase family 1*

-0.634

0.0245

6

17.7

Q9CPY7

leucine aminopeptidase 3

-0.629

0.0926

4

17.5

Q8R0Y6

aldehyde dehydrogenase 1 family, member L1

-0.566

0.0747

5

15.6

P12710

fatty acid binding protein 1*

0.524

0.221

17

50.8

P53657

pyruvate kinase liver and red blood cell*

0.51

0.278

8

35.3

  1. Top list of differentially regulated proteins identified using PPINGUIN. Proteins marked with an asterisk (*) have previously been associated with diabesity [44]. P-values are calculated using one-sample t-test (null hypothesis: log2(NZO_HFD/SJL_SD) = 0). P-values are not used as a criterion for differential expression and are not corrected for multiple testing. With an increasing number of replicates in future studies significance of the p-values may be improved.