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Figure 1 | BMC Bioinformatics

Figure 1

From: miRTrail - a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseases

Figure 1

Workflow. Workflow of miRTrail. User submits two RNA sets (one is the set of deregulated miRNAs, the other is the set of deregulated mRNAs, both for the same disease). Orange color represents information flow of miRNA-related information: For each provided miRNA, the target mRNAs are determined (based on microCosm predictions or custom, uploaded interactions). This information then is used by miRTrail, indicated by the red arrow. In general, red color represents flow of mRNA-related information: The uploaded mRNA set as well as the miRNA targets are used in GeneTrail to perform ORAs as described in the "Methods"-section. Blue color represents information flow of results-related information, e.g. for the overlap of pathway sets. Finally in the results, the network analysis allows for targeted inspection of the provided information, based e.g. on miRNA families-related subnetworks. The modular design of miRTrail becomes visible here, also allowing for convenient extension of future analyses and usage for a diversity of different organisms.

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