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Table 2 Performance on independent datasets

From: Grading amino acid properties increased accuracies of single point mutation on protein stability prediction

Test set

Q3

MCC

Q(N)

Q(+)

Q(-)

Specificity

(N)

Specificity

(+)

Specificity

(-)

PPV

(P (N))

PPV(P (+))

PPV

(P (-))

NPV

(N)

NPV

(+)

NPV

(-)

MCC

(C(N))

MCC

(C(+))

MCC

(C(-))

clean.TEST_

May11

71.82

0.51

80.65

63.21

62.35

66.90

92.10

92.17

71.19

72.75

72.72

77.13

88.34

88.09

0.48

0.58

0.51

clean.S1615

72.71

0.54

79.68

66.79

65.62

70.26

91.45

92.14

72.73

71.95

73.15

76.98

89.21

88.94

0.50

0.60

0.55

clean.S388

74.49

0.56

81.84

67.70

66.59

70.29

92.67

93.19

73.16

75.37

76.28

79.31

89.57

89.29

0.52

0.63

0.57

clean.PoPMuSiC

72.17

0.53

76.57

68.40

66.94

72.04

90.48

91.18

72.94

70.57

71.34

75.39

89.60

89.22

0.48

0.59

0.56

clean.Potapov

71.58

0.52

79.30

64.47

63.80

68.34

91.77

91.77

71.08

72.41

72.11

76.97

88.42

88.21

0.48

0.58

0.52

Average

72.55

0.53

79.61

66.11

65.06

69.57

91.69

92.09

72.22

72.61

73.12

77.16

89.03

88.75

0.49

0.60

0.54

  1. For notation see Table 1. Independent test set details and statistics see Table S1 and S2