Grading amino acid properties increased accuracies of single point mutation on protein stability prediction

Liu, Jianguo; Kang, Xianjiang

doi:10.1186/1471-2105-13-44

BMC Bioinformatics

Table 3 The amino acid property scores used in the AAproperty15 encoding scheme

From: Grading amino acid properties increased accuracies of single point mutation on protein stability prediction

AA	Steric parameter	Hydrogen Bond Donors	Hydrophobicity scale	Hydrophilicity scale	Average Accessible surface area	van der Waals Parameter R0	van der Waals Parameter Epsilon	Free Energy of solution in water	Average side chain orientation Angle	Polarity	Isoelectric point	He	Ee	Ce	KDe
A	0.510	0.169	0.471	0.279	0.141	0.294	0.000	0.262	0.512	0.000	0.404	0.811	0.667	0.700	0.858
R	0.667	0.726	0.321	1.000	0.905	0.529	0.327	0.169	0.372	1.000	1.000	0.777	0.691	0.719	0.011
N	0.745	0.390	0.164	0.658	0.510	0.235	0.140	0.313	0.116	0.065	0.330	0.691	0.655	0.790	0.029
D	0.745	0.304	0.021	0.793	0.515	0.235	0.140	0.601	0.140	0.956	0.000	0.725	0.624	0.783	0.029
C	0.608	0.314	0.760	0.072	0.000	0.559	0.140	0.947	0.907	0.028	0.285	0.661	0.804	0.737	0.924
Q	0.667	0.531	0.178	0.649	0.608	0.529	0.140	0.416	0.023	0.068	0.360	0.778	0.683	0.722	0.029
E	0.667	0.482	0.092	0.883	0.602	0.529	0.140	0.561	0.163	0.960	0.056	0.812	0.652	0.707	0.029
G	0.000	0.000	0.275	0.189	0.103	0.000	0.000	0.240	0.581	0.000	0.401	0.619	0.665	0.821	0.401
H	0.686	0.554	0.326	0.468	0.402	0.529	0.140	0.313	0.581	0.992	0.603	0.715	0.754	0.732	0.039
I	1.000	0.650	1.000	0.000	0.083	0.824	0.308	0.424	0.930	0.003	0.407	0.734	0.844	0.658	0.989
L	0.961	0.650	0.734	0.081	0.138	0.824	0.308	0.463	0.907	0.003	0.402	0.792	0.768	0.664	0.978
K	0.667	0.692	0.000	0.568	1.000	0.529	0.327	0.313	0.000	0.952	0.872	0.755	0.701	0.731	0.020
M	0.765	0.612	0.603	0.171	0.206	0.765	0.308	0.405	0.814	0.028	0.372	0.794	0.763	0.665	0.870
F	0.686	0.772	0.665	0.000	0.114	0.853	0.682	0.462	1.000	0.007	0.339	0.747	0.807	0.676	0.943
P	0.353	0.372	0.012	0.198	0.411	0.588	0.271	0.000	0.302	0.030	0.442	0.629	0.608	0.835	0.168
S	0.520	0.172	0.155	0.477	0.303	0.206	0.000	0.240	0.419	0.032	0.364	0.681	0.711	0.773	0.310
T	0.490	0.349	0.256	0.523	0.337	0.235	0.140	0.313	0.419	0.032	0.362	0.667	0.780	0.748	0.332
W	0.686	1.000	0.681	0.207	0.219	1.000	1.000	0.537	0.674	0.040	0.390	0.759	0.815	0.661	0.289
Y	0.686	0.796	0.591	0.477	0.454	0.853	0.682	1.000	0.419	0.031	0.362	0.721	0.813	0.692	0.214
V	0.745	0.487	0.859	0.036	0.094	0.647	0.234	0.369	0.674	0.003	0.399	0.714	0.864	0.655	0.985

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ISSN: 1471-2105

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