Figure 3

Recurrent correlations display from the epigenetic to the protein level. Phenotypic outcomes at the level of histone acetylation, chromatin binding, mRNA production and nuclear protein abundance are shown for the genes that form the ESC core network on each layer. Nodes are colored corresponding to the gene value on a yellow-blue color scale. Correlations between the vectors of time-resolved values associated to each gene are highlighted by connecting the corresponding nodes with a yellow line (for positive correlations) or a red line (for negative correlations). Left hand side: all correlations with p-value < 0.05 (i.e. coefficient greater than 0.997) are represented as connections between nodes for each layer. Right hand side: only recurrent correlations on at least two layers are displayed for the corresponding layers. The layer of chromatin bound RNA polymerase II is not shown because there are no recurrent correlations on that layer.