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Figure 6 | BMC Bioinformatics

Figure 6

From: Correlation set analysis: detecting active regulators in disease populations using prior causal knowledge

Figure 6

CSA identifies important regulators expressed in adipocytes and monocytes. (a) Gene expression of PLIN1 in different tissues. (b) PLIN1 and some of its downstream regulatees. (c) CCR1 and its upstream regulators (red nodes) and downstream regulatees (blue nodes). (d) Gene expression of CCR1 in different tissues. (a) and (d) are from BioGPS, which show that PLIN1 and CCR1 are uniquely expressed in adipocytes and Macrophages, respectively. (b) PLIN1 regulates 37 regulatees in adipose tissue. (c) CCR1 is regulated by numerous regulators in the causal network. CSA identified 14 potential active regulators of CCR1 in the adipose tissue (red). CCR1 is a regulator that can regulate several downstream regulatees (blue); at the same time, CCR1 is also regulated by many other regulators. These regulators regulate each other and also CCR1's regulatees.

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BMC Bioinformatics

ISSN: 1471-2105

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