Figure 8

Regulators enriched for Stromal-1 and Stromal-2 signatures. Red nodes are regulators. Blue nodes are genes in Stromal-1 signatures. Green nodes are genes in Stromal-2 signatures. We did not find any regulator enriched for Germinal Center B-cell signature works in both cohorts. Instead, CSA identified 55 and 11 regulators enriched for Stromal-1 and -2 signatures in both cohorts. Furthermore, the regulatory model showed that the majority of genes in Stromal-2 signature are regulated by regulators that also regulate Stromal-1 signature.