Correlation set analysis: detecting active regulators in disease populations using prior causal knowledge

BMC Bioinformatics

Table 1 Top 15 regulators found in CHOP and R-CHOP cohorts

	No. of Regulatees^a		Germinal Center B cell^b		Stromal-1^c		Stromal-2^d
Regulator	CHOP	R-CHOP	CHOP	R-CHOP	CHOP	R-CHOP	CHOP	R-CHOP
TGFB1	723	632	0.2379	0.3081	1.36E-12	2.30E-14	0.0003	7.36E-05
IFNG	624	553	0.5868	0.6600	0.0041	0.0006	0.1928	0.1008
MYC	439	410	0.1870	0.2094	0.0013	0.0005	0.1427	0.0673
IL6	370	317	0.5962	0.6678	0.0281	0.0497	0.2135	0.0854
MYCN	272	248	0.3566	0.3908	8.22E-06	7.20E-06	0.4979	0.5463
ERBB2	253	219	0.3731	0.3666	7.50E-07	2.79E-07	0.0149	0.0088
IFNB1	251	233	0.3864	0.4139	0.1869	0.1256	0.4674	0.4826
IL10	249	221	0.3727	0.3672	0.0950	0.0543	0.1307	0.1080
CDKN1A	234	224	0.3704	0.3680	0.0953	0.0554	0.4817	0.2436
F2	233	212	0.4139	0.4484	0.0009	0.000372	0.0409	0.0317
IL2	205	188	0.4605	0.4912	0.3236	0.4066	0.6388	0.6769
CCND1	204	184	0.4622	0.4987	7.86E-05	2.38E-05	0.0013	0.000777
VEGFA	189	170	0.4894	0.5259	3.27E-05	3.60E-05	1.86E-06	7.91E-06
MAPK1	183	166	0.5006	0.5340	0.0063	0.003266	0.3192	0.3550
TNFSF11	166	150	0.1038	0.0898	0.5435	0.6276	0.1905	0.1714

^anumber of cohesive regulatees.
^{b, c, d}the enrichment p-values of Germinal Center B cell, Stromal-1 and Stromal-2 signatures in CHOP and R-CHOP groups.

ISSN: 1471-2105