Skip to main content

Table 1 Top 15 regulators found in CHOP and R-CHOP cohorts

From: Correlation set analysis: detecting active regulators in disease populations using prior causal knowledge

  No. of Regulateesa Germinal Center B cellb Stromal-1c Stromal-2d
Regulator CHOP R-CHOP CHOP R-CHOP CHOP R-CHOP CHOP R-CHOP
TGFB1 723 632 0.2379 0.3081 1.36E-12 2.30E-14 0.0003 7.36E-05
IFNG 624 553 0.5868 0.6600 0.0041 0.0006 0.1928 0.1008
MYC 439 410 0.1870 0.2094 0.0013 0.0005 0.1427 0.0673
IL6 370 317 0.5962 0.6678 0.0281 0.0497 0.2135 0.0854
MYCN 272 248 0.3566 0.3908 8.22E-06 7.20E-06 0.4979 0.5463
ERBB2 253 219 0.3731 0.3666 7.50E-07 2.79E-07 0.0149 0.0088
IFNB1 251 233 0.3864 0.4139 0.1869 0.1256 0.4674 0.4826
IL10 249 221 0.3727 0.3672 0.0950 0.0543 0.1307 0.1080
CDKN1A 234 224 0.3704 0.3680 0.0953 0.0554 0.4817 0.2436
F2 233 212 0.4139 0.4484 0.0009 0.000372 0.0409 0.0317
IL2 205 188 0.4605 0.4912 0.3236 0.4066 0.6388 0.6769
CCND1 204 184 0.4622 0.4987 7.86E-05 2.38E-05 0.0013 0.000777
VEGFA 189 170 0.4894 0.5259 3.27E-05 3.60E-05 1.86E-06 7.91E-06
MAPK1 183 166 0.5006 0.5340 0.0063 0.003266 0.3192 0.3550
TNFSF11 166 150 0.1038 0.0898 0.5435 0.6276 0.1905 0.1714
  1. anumber of cohesive regulatees.
  2. b, c, dthe enrichment p-values of Germinal Center B cell, Stromal-1 and Stromal-2 signatures in CHOP and R-CHOP groups.