Table 1 The direction of covariates effect in RIM_minP (Table 1A) and RIM_BIC (Table 1B) models for 9 MDD related genes selected from the literature
| S | Age | Alcohol | Antidep | pH | PMI | Suicide | Co-appearance T1 | Concordance T2 |
Ratio R = T2/T1 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | B | C | D | E | A | B | C | D | E | A | B | C | D | E | A | B | C | D | E | A | B | C | D | E | A | B | C | D | E | ||||
| VGF | 0 | 0 | -1 | 0 | -1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 7 | 7 | |
| SST | 0 | 0 | -1 | 0 | -1 | 1 | 1 | 0 | 1 | 0 | 0 | -1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 7 | 7 | |
| CNP | 0 | 1 | 0 | 1 | 0 | -1 | 0 | 0 | 1 | 0 | -1 | 0 | 1 | 0 | -1 | 0 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 1 | 0 | 0 | 5 | 2 | |
| NPY | 0 | -1 | -1 | 0 | -1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 1 | 1 | 1 | 10 | 7 | |
| TAC1 | 0 | -1 | -1 | 0 | -1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 1 | 0 | 1 | 7 | 5 | |
| MBP | 0 | 0 | 0 | 1 | 1 | 0 | -1 | 0 | 1 | 0 | -1 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | -S1 | 0 | 1 | 0 | -1 | 5 | 2 | |
| MOBP | 0 | 0 | 0 | 0 | 1 | 0 | -1 | 1 | 0 | 0 | -1 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | -1 | 0 | 1 | -1 | -1 | 8 | 4 | |
| RGS4 | -1 | 0 | 0 | 0 | -1 | 0 | 1 | -1 | 1 | 0 | 1 | 0 | -1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 6 | 3 | |
| HTR2A | 0 | -1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | -1 | -1 | 0 | -1 | 0 | -1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 5 | 3 | |
| Total | T1 = 60 | T2 = 40 | R = T2/T1 = 0.67 | ||||||||||||||||||||||||||||||
| p-value | 0.39 | 0.014 | |||||||||||||||||||||||||||||||
| Age | Alcohol | Antidep | pH | PMI | Suicide | Co-appearance T1 | Concordance T2 | Ratio R = T2/T1 | |||||||||||||||||||||||||
| A | B | C | D | E | A | B | C | D | E | A | B | C | D | E | A | B | C | D | E | A | B | C | D | E | A | B | C | D | E | 1 | 1 | ||
| VGF | 0 | 0 | -1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 7 | 7 | |
| SST | -1 | 0 | -1 | -1 | -1 | 0 | 1 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 3 | 3 | |
| CNP | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | -1 | 0 | 7 | 7 | |
| NPY | -1 | 0 | -1 | -1 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 | 6 | |
| TAC1 | -1 | 0 | -1 | -1 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | |
| MBP | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 3 | 3 | |
| MOBP | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 3 | 3 | |
| RGS4 | -1 | 0 | 0 | -1 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | |
| HTR2A | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | -1 | -1 | 0 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | |
| Total | T1 = 32 | T2 = 32 | R = T2/T1 = 1 | ||||||||||||||||||||||||||||||
| p-value | 0.011 | 0.005 | |||||||||||||||||||||||||||||||