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Table 1 The direction of covariates effect in RIM_minP (Table 1A) and RIM_BIC (Table 1B) models for 9 MDD related genes selected from the literature

From: Detecting disease-associated genes with confounding variable adjustment and the impact on genomic meta-analysis: With application to major depressive disorder

S Age Alcohol Antidep pH PMI Suicide Co-appearance T1 Concordance T2 Ratio R
= T2/T1
  A B C D E A B C D E A B C D E A B C D E A B C D E A B C D E    
VGF 0 0 -1 0 -1 1 1 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 7 7  
SST 0 0 -1 0 -1 1 1 0 1 0 0 -1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 1 1 7 7  
CNP 0 1 0 1 0 -1 0 0 1 0 -1 0 1 0 -1 0 -1 0 0 0 0 0 0 0 -1 0 0 1 0 0 5 2  
NPY 0 -1 -1 0 -1 1 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 -1 1 1 1 10 7  
TAC1 0 -1 -1 0 -1 1 0 0 1 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 -1 1 0 1 7 5  
MBP 0 0 0 1 1 0 -1 0 1 0 -1 0 0 0 0 0 -1 0 0 0 0 0 1 0 0 -S1 0 1 0 -1 5 2  
MOBP 0 0 0 0 1 0 -1 1 0 0 -1 0 0 -1 0 0 0 0 0 0 0 -1 0 0 0 -1 0 1 -1 -1 8 4  
RGS4 -1 0 0 0 -1 0 1 -1 1 0 1 0 -1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 1 6 3  
HTR2A 0 -1 0 1 0 0 1 0 0 -1 -1 0 -1 0 -1 0 0 0 1 0 1 0 0 0 0 0 0 -1 0 0 5 3  
                             Total T1 = 60 T2 = 40 R = T2/T1 = 0.67
                             p-value 0.39   0.014
  Age Alcohol Antidep pH PMI Suicide Co-appearance T1 Concordance T2 Ratio R = T2/T1
  A B C D E A B C D E A B C D E A B C D E A B C D E A B C D E 1 1  
VGF 0 0 -1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 7 7  
SST -1 0 -1 -1 -1 0 1 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 3 3  
CNP 1 0 0 1 1 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 0 0 0 -1 0 7 7  
NPY -1 0 -1 -1 -1 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 1 6 6  
TAC1 -1 0 -1 -1 -1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1  
MBP 0 0 0 1 1 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 3 3  
MOBP 1 0 0 1 1 0 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 3 3  
RGS4 -1 0 0 -1 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1  
HTR2A 0 0 0 1 0 0 1 0 0 0 0 -1 -1 0 0 0 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 1 1  
                             Total T1 = 32 T2 = 32 R = T2/T1 = 1
                             p-value 0.011   0.005
  1. * 0: variable not included in the model; 1: appear in the model with positive effect size; -1: appear in the model with negative effect size.
  2. A: MD1_ACC, B: MD2_ACC, C: MD3_ACC, D: MD1_AMY, E: MD3_AMY