Figure 1
From: F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks
Exemplary metabolic network MetNet before and after preprocessing. (a) MetNet consists of eight metabolites (A,…,H), and thirteen reactions (1,…,13), whereof six reactions are irreversible. Metabolites are depicted as nodes while reactions are depicted as arrows. Reversible reactions are indicated by double arrowheads. (b) MetNet after preprocessing where dead-end metabolites and blocked reactions were removed and fully coupled reactions were merged iteratively. This resulted in the removal of the blocked reaction 13 and the merging of the pairs of equivalent reactions (1,2), (8,9) and (11,12)).