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Table 1 Yeast-polarization model: parameter estimates and mean relative error (% Error) for MCEM 2 MLEs, SGD MLEs (SGD 2 initialized with values exhibiting 12% mean relative error), and Poisson method point estimates, along with the MCEM 2 and Poisson method 68% confidence intervals (CIs) for each parameter

From: Accelerated maximum likelihood parameter estimation for stochastic biochemical systems

Method

Type

θ 1

θ 2

θ 3

θ 4

θ 5

θ 6

θ 7

θ 8

% Error

 

True

.38

.04

.082

.12

.021

.1

.005

13.21

 
 

Lower

n/a

.014

.076

n/a

.021

.089

.005

7.386

 

MCEM2

MLE

.0005

.026

.081

.0009

.022

.104

.006

11.479

34.7

 

Upper

n/a

.048

.087

n/a

.024

.122

.006

17.839

 
 

Lower

.002

.003

.080

.0001

.018

.069

.004

.0005

 

Poisson

Mean

2.233

.020

.086

.016

.019

.083

.005

1.719

93.3

 

Upper

4.749

.033

.092

.027

.021

.095

.005

3.972

 

SGD1

MLE

1.000

.798

.334

1.425

Inf

.591

.039

1.024

Inf

SGD2

MLE

.439

.043

.042

3.241

Inf

.029

.003

2.649

Inf